Pub. Date : 2020 Feb 7
PMID : 31896574
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |
| 2 | Here, we report that MMT1 and MMT2 expression is transcriptionally regulated by two pathways: the low-iron sensing transcription factor Aft1 and the oxidant-sensing transcription factor Yap1. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |
| 3 | We defined Aft1- and Yap1-dependent transcriptional sites in the MMT1 promoter that are necessary for low iron- or oxidant-mediated MMT1 expression. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |
| 4 | Our findings reveal that both MMT1 and MMT2 are induced under low-iron conditions and that the low-iron regulator Aft1 is required for this induction. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |
| 5 | Our findings reveal that both MMT1 and MMT2 are induced under low-iron conditions and that the low-iron regulator Aft1 is required for this induction. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |
| 6 | We further uncover an Aft1-binding site in the MMT1 promoter sufficient for inducing MMT1 transcription and identify an MMT2 promoter region required for low-iron induction. | Iron | DNA-binding transcription factor AFT1 | Saccharomyces cerevisiae S288C |