Pub. Date : 2020 Feb
PMID : 31894502
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tizoxanide induces autophagy by inhibiting PI3K/Akt/mTOR pathway in RAW264.7 macrophage cells. | tizoxanide | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | In this study, we investigated the effects of TIZ on autophagy by regulating the PI3K/Akt/mTOR signaling pathway. | tizoxanide | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Treatment with TIZ increased the Beclin-1 expression level and inhibited PI3K, Akt, mTOR, and ULK1 activation. | tizoxanide | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | These data suggested that TIZ may induce autophagy by inhibiting the Akt/mTOR/ULK1 signaling pathway in macrophages and other cells. | tizoxanide | thymoma viral proto-oncogene 1 | Mus musculus |