Pub. Date : 2020 Feb
PMID : 31894313
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin alleviates endometrial hyperplasia through the UCA1/miR-144/TGF-beta1/AKT signaling pathway. | Metformin | urothelial cancer associated 1 | Homo sapiens |
| 2 | Reverse transcription-quantitative polymerase chain reaction, western blot and immunohistochemistry (IHC) assays were used to study the effects of Met and tamoxifen on the expression levels of urothelial cancer associated 1 (UCA1), microRNA-144 (miR-144) and other factors along the transforming growth factor-beta1 (TGF-beta1)/protein kinase B (AKT) signaling pathway. | Metformin | urothelial cancer associated 1 | Homo sapiens |
| 3 | Reverse transcription-quantitative polymerase chain reaction, western blot and immunohistochemistry (IHC) assays were used to study the effects of Met and tamoxifen on the expression levels of urothelial cancer associated 1 (UCA1), microRNA-144 (miR-144) and other factors along the transforming growth factor-beta1 (TGF-beta1)/protein kinase B (AKT) signaling pathway. | Metformin | urothelial cancer associated 1 | Homo sapiens |
| 4 | By contrast, Met reduced cell viability, promoted cell apoptosis, and reduced the expression levels of UCA1, TGF-beta and p-AKT, while upregulating the expression of miR-144 and active Caspase-3 in a dose-dependent manner. | Metformin | urothelial cancer associated 1 | Homo sapiens |
| 5 | In conclusion, the current study suggested that Met reduces the risk of EH by reducing the expression levels of UCA1, TGF-beta and p-AKT, while increasing the levels of miR-144 and active Caspase-3 in a dose-dependent manner. | Metformin | urothelial cancer associated 1 | Homo sapiens |