Title : Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers.

Pub. Date : 2020 Mar

PMID : 31888882






5 Functional Relationships(s)
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1 After stratification by UGT1A1 phenotypes, there was a significant decrease in total bilirubin among all phenotypes, conjugated bilirubin among intermediate metabolizers, and unconjugated bilirubin among normal and intermediate metabolizers. Bilirubin UDP glucuronosyltransferase family 1 member A1 Homo sapiens
2 After stratification by UGT1A1 phenotypes, there was a significant decrease in total bilirubin among all phenotypes, conjugated bilirubin among intermediate metabolizers, and unconjugated bilirubin among normal and intermediate metabolizers. Bilirubin UDP glucuronosyltransferase family 1 member A1 Homo sapiens
3 After stratification by UGT1A1 phenotypes, there was a significant decrease in total bilirubin among all phenotypes, conjugated bilirubin among intermediate metabolizers, and unconjugated bilirubin among normal and intermediate metabolizers. Bilirubin UDP glucuronosyltransferase family 1 member A1 Homo sapiens
4 The data also show that UGT1A1 genotype predicts serum bilirubin levels at baseline, but this relationship is lost after efavirenz treatment. Bilirubin UDP glucuronosyltransferase family 1 member A1 Homo sapiens
5 Our data suggest that efavirenz may alter bilirubin disposition mainly through induction of UGT1A1 metabolism and efflux through multidrug resistance-associated protein 2. Bilirubin UDP glucuronosyltransferase family 1 member A1 Homo sapiens