Title : p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease.

Pub. Date : 2020 Feb 1

PMID : 31881179






2 Functional Relationships(s)
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1 Here, we demonstrate that dynamin-related protein 1(DRP1) is a substrate for p38 MAPK, mutant alpha-synuclein overexpression in SN4741 cell caused p38 MAPK activation, p38 MAPK-mediated phosphorylation DRP1 at serine 616 to activate DRP1 and is associated with increased mitochondrial fission, which resulted in mitochondrial dysfunction and neuronal loss. Serine dynamin 1-like Mus musculus
2 Here, we demonstrate that dynamin-related protein 1(DRP1) is a substrate for p38 MAPK, mutant alpha-synuclein overexpression in SN4741 cell caused p38 MAPK activation, p38 MAPK-mediated phosphorylation DRP1 at serine 616 to activate DRP1 and is associated with increased mitochondrial fission, which resulted in mitochondrial dysfunction and neuronal loss. Serine dynamin 1-like Mus musculus