Pub. Date : 2019 Dec 21
PMID : 31877751
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification and Characterization of a New Platinum-Induced TP53 Mutation in MDAH Ovarian Cancer Cells. | Platinum | tumor protein p53 | Homo sapiens |
| 2 | Interestingly, we found that PT-resistant MDAH cells acquired in the TP53 gene a novel secondary mutation (i.e., S185G) that accompanied the R273H typical of MDAH cells. | Platinum | tumor protein p53 | Homo sapiens |
| 3 | The double p53S185G/R273H mutant increases the resistance to PT in a TP53 null EOC cellular model. | Platinum | tumor protein p53 | Homo sapiens |
| 4 | The double p53S185G/R273H mutant increases the resistance to PT in a TP53 null EOC cellular model. | Platinum | tumor protein p53 | Homo sapiens |
| 5 | Overall, we show how the selective pressure of PT is able to induce additional mutation in an already mutant TP53 gene in EOC and how this event could contribute to the acquisition of novel cellular phenotypes. | Platinum | tumor protein p53 | Homo sapiens |