Pub. Date : 2020 Feb
PMID : 31876196
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After BPA-exposure, expression of ERalpha increased significantly in pSS patients, while that of ERbeta remained unchanged. | bisphenol A | estrogen receptor 1 | Homo sapiens |
| 2 | BPA increased HLA-DR on moDCs of pSS patients via ERalpha, and promoted the secretion of IL6 and IL12. | bisphenol A | estrogen receptor 1 | Homo sapiens |
| 3 | When co-cultured with BPA-treated moDCs, cytokines (IFN-gamma, IL4, IL17, IL10) and transcription factors (T-bet, Gata3, RoR-gammat, Foxp3) of CD4+ T cells showed imbalance of Th1/Th2/Th17/Treg polarization, with Th1 and Th17 dominating.Conclusions: BPA altered the function of moDCs through ERalpha, including antigen capture, secretion of inflammatory factors, and ability to stimulate T cells, as well as accelerated the progression and further deterioration of pSS. | bisphenol A | estrogen receptor 1 | Homo sapiens |