Pub. Date : 2020 Sep
PMID : 31873757
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression. | NAD | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | In this study, ERK1/2 regulation of cellular nicotinamide adenine dinucleotide (NAD) and PGC-1alpha were explored. | NAD | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | In this study, ERK1/2 regulation of cellular nicotinamide adenine dinucleotide (NAD) and PGC-1alpha were explored. | NAD | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | Inhibition of ERK1/2 activation during AKI in mice using the MEK1/2 inhibitor, trametinib, attenuated renal cortical oxidized NAD (NAD+) depletion. | NAD | mitogen-activated protein kinase 3 | Mus musculus |
| 5 | Inhibition of ERK1/2 activation during AKI in mice using the MEK1/2 inhibitor, trametinib, attenuated renal cortical oxidized NAD (NAD+) depletion. | NAD | mitogen-activated protein kinase 3 | Mus musculus |
| 6 | The rate-limiting NAD biosynthesis salvage enzyme, NAMPT, decreased following AKI, and this decrease was prevented by ERK1/2 inhibition. | NAD | mitogen-activated protein kinase 3 | Mus musculus |
| 7 | In addition, ERK1/2 activation increased acetylated PGC-1alpha, the less active form, whereas inhibition of ERK1/2 activation prevented an increase in acetylated PGC-1alpha after AKI through SIRT1 and NAD+ attenuation. | NAD | mitogen-activated protein kinase 3 | Mus musculus |
| 8 | These results implicate IR-induced ERK1/2 activation as an important contributor to the downregulation of both PGC-1alpha and NAD+ pathways that ultimately decrease cellular metabolism and renal function. | NAD | mitogen-activated protein kinase 3 | Mus musculus |
| 9 | Inhibition of ERK1/2 activation prior to the initiation of IR injury attenuated decreases in PGC-1alpha and NAD+ and prevented kidney dysfunction. | NAD | mitogen-activated protein kinase 3 | Mus musculus |