Title : The small fiber neuropathy NaV1.7 I228M mutation: impaired neurite integrity via bioenergetic and mitotoxic mechanisms, and protection by dexpramipexole.

Pub. Date : 2020 Feb 1

PMID : 31851560






4 Functional Relationships(s)
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Protein Name
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1 We have hypothesized that sustained sodium influx due to the expression of SFN-associated sodium channel variants may trigger an energetic deficit in neurons which contributes to degeneration and loss of nerve fibers in SFN. Sodium RNA exonuclease 2 Homo sapiens
2 We have hypothesized that sustained sodium influx due to the expression of SFN-associated sodium channel variants may trigger an energetic deficit in neurons which contributes to degeneration and loss of nerve fibers in SFN. Sodium RNA exonuclease 2 Homo sapiens
3 We have hypothesized that sustained sodium influx due to the expression of SFN-associated sodium channel variants may trigger an energetic deficit in neurons which contributes to degeneration and loss of nerve fibers in SFN. Sodium RNA exonuclease 2 Homo sapiens
4 We have hypothesized that sustained sodium influx due to the expression of SFN-associated sodium channel variants may trigger an energetic deficit in neurons which contributes to degeneration and loss of nerve fibers in SFN. Sodium RNA exonuclease 2 Homo sapiens