Pub. Date : 2020 Jun
PMID : 31846070
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extensive in vitro and preclinical research has demonstrated that niclosamide was found to exert potent anticancer and anti-inflammatory properties by targeting STAT3, p65 NF-kappaB, and NFATc-1 signaling paradigm with minimal host toxicity. | Niclosamide | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Additionally, our results provided a preclinical rationale in imiquimod (IMQ)-induced BALB/c mouse model, where niclosamide diligently mitigated the IMQ-induced epidermal hyperplasia and inflammation by downregulating STAT3, p65 NF-kappaB, and NFATc-1 transcription factors along with Akt, Ki-67, and ICAM-1 protein expression. | Niclosamide | signal transducer and activator of transcription 3 | Mus musculus |