Title : The characteristics and biological significance of NPC2: Mutation and disease.

Pub. Date : 2019 Oct - Dec

PMID : 31843136






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Linkage studies in multiplex NPC families and genetic complementation research revealed two disease genes, NPC1 and NPC2, both of which are important transporters for cholesterol trafficking. Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens
2 NPC2 executes cholesterol-transport function through protein-protein interaction with NPC1 as well as through protein-membrane interaction directly with membrane of late endosome and lysosome. Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens