Pub. Date : 2020 Feb 1
PMID : 31841390
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | COX-2 derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease. | Nicotine | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 2 | In previous studies, we showed that nicotine induces COX-2 expression in vivo and in vitro and that the administration of nicotine in vivo worsens the severity of renal injury in a model of sub-total renal ablation. | Nicotine | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 3 | Treatment with the COX-2 inhibitor NS-398 resulted in complete inhibition of all prostaglandins studied and ameliorated renal injury and proteinuria in 5/6Nx rats on nicotine but not in 5/6 Nx rats on tap water. | Nicotine | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 4 | Nicotine also reduced the expression of megalin in all groups examined which was partially prevented by COX-2 inhibition. | Nicotine | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |