Title : COX-2-derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease.

Pub. Date : 2020 Feb 1

PMID : 31841390






4 Functional Relationships(s)
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1 COX-2 derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease. Nicotine cytochrome c oxidase II, mitochondrial Rattus norvegicus
2 In previous studies, we showed that nicotine induces COX-2 expression in vivo and in vitro and that the administration of nicotine in vivo worsens the severity of renal injury in a model of sub-total renal ablation. Nicotine cytochrome c oxidase II, mitochondrial Rattus norvegicus
3 Treatment with the COX-2 inhibitor NS-398 resulted in complete inhibition of all prostaglandins studied and ameliorated renal injury and proteinuria in 5/6Nx rats on nicotine but not in 5/6 Nx rats on tap water. Nicotine cytochrome c oxidase II, mitochondrial Rattus norvegicus
4 Nicotine also reduced the expression of megalin in all groups examined which was partially prevented by COX-2 inhibition. Nicotine cytochrome c oxidase II, mitochondrial Rattus norvegicus