Pub. Date : 1988 Nov
PMID : 3183973
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic ethanol consumption results in the induction of a specific hepatic cytochrome P-450 (P450IIE1). | Ethanol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Chronic ethanol consumption results in the induction of a specific hepatic cytochrome P-450 (P450IIE1). | Ethanol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | By administering ethanol in the drinking water, or as part of a low-fat (5% of energy) liquid diet, a significant induction of P450IIE1 and of the activities of the microsomal ethanol oxidizing system and p-nitrophenol hydroxylase was demonstrated in the absence of any significant increase in blood acetone with minimal increase in liver total lipids. | Ethanol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Induction of P450IIE1 was comparable with the low or normal fat-containing diets, but MEOS activity rose more with the latter, possibly reflecting a potentiating effect of dietary fat on ethanol oxidation by P-450 enzymes other than P450IIE1. | Ethanol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | Thus, the induction of P450IIE1 after chronic ethanol consumption can be attributed to ethanol itself, but dietary fat can potentiate the induction of the microsomal ethanol oxidizing system and of p-nitrophenol hydroxylase. | Ethanol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | Thus, the induction of P450IIE1 after chronic ethanol consumption can be attributed to ethanol itself, but dietary fat can potentiate the induction of the microsomal ethanol oxidizing system and of p-nitrophenol hydroxylase. | Ethanol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | Thus, the induction of P450IIE1 after chronic ethanol consumption can be attributed to ethanol itself, but dietary fat can potentiate the induction of the microsomal ethanol oxidizing system and of p-nitrophenol hydroxylase. | Ethanol | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |