Pub. Date : 2020 Apr
PMID : 31838663
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tacrolimus Inhibits TNF-alpha/IL-17A-Produced pro-Inflammatory Effect on Human Keratinocytes by Regulating IkappaBzeta. | Tacrolimus | interleukin 17A | Homo sapiens |
| 2 | This study aimed to investigate the potential regulatory effect of tacrolimus on TNF-alpha/ IL-17A-costimulated human keratinocytes in the mimic psoriatic microenvironment. | Tacrolimus | interleukin 17A | Homo sapiens |
| 3 | Tacrolimus significantly inhibited TNF-alpha/IL-17A-induced IL-36gamma, CCL-20, IL-1beta, and S100-A9 expression at gene level and IL-36gamma and CCL-20 expression at protein level. | Tacrolimus | interleukin 17A | Homo sapiens |
| 4 | We further discovered TNF-alpha/IL-17A induced significant IkappaBzeta mRNA and protein expression in NHKs, which could be inhibited by tacrolimus. | Tacrolimus | interleukin 17A | Homo sapiens |
| 5 | Tacrolimus can inhibit pro-inflammatory synergistic action of TNF-alpha/IL-17A on human keratinocytes by regulating IkappaBzeta expression. | Tacrolimus | interleukin 17A | Homo sapiens |