Title : Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway.

Pub. Date : 2020 Feb

PMID : 31830378






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway. Metformin AKT serine/threonine kinase 1 Homo sapiens
2 Both the in vitro and in vivo results showed that aloin and MET alone as well as combination treatment activated the PI3K/AKT/mTOR pathway. Metformin AKT serine/threonine kinase 1 Homo sapiens
3 Overall, our research demonstrated that the concomitant treatment with aloin and MET enhances the antitumor effect by inhibiting the growth and invasion as well as inducing apoptosis and autophagy in HCC through PI3K/AKT/mTOR pathway. Metformin AKT serine/threonine kinase 1 Homo sapiens