Title : Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation.

Pub. Date : 2020 Jan

PMID : 31818478






1 Functional Relationships(s)
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1 In particular, compound 6c bearing a pyrrolidine group showed the highest activities against self- and Cu2+-induced Abeta1-42 aggregation (70.65% and 54.89% at 25.0 microM, respectively), highly selective inhibition towards AChE and MAO-B (IC50 = 7.15 muM and 0.43 muM respectively), good antioxidant ability and metal-chelating property. Copper acetylcholinesterase (Cartwright blood group) Homo sapiens