Pub. Date : 2020 May 1
PMID : 31816046
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Abeta42 level in acidic pH. | histidine-pyridine-histidine-3 | presenilin 1 | Homo sapiens |
| 2 | Among the histidines facing the luminal side of presenilin (PS) 1, which is the catalytic subunit of gamma-secretase, point mutations at H131 had no effect on the Abeta42 production ratio in an acidic environment. | histidine-pyridine-histidine-3 | presenilin 1 | Homo sapiens |
| 3 | We also observed an increase in Abeta42 ratio when histidine was introduced into N137 of PS2, which is the corresponding residue of H131 in PS1. | histidine-pyridine-histidine-3 | presenilin 1 | Homo sapiens |