Title : Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal α-Helical Region of Htt.

Pub. Date : 2020 Feb 4

PMID : 31814404






3 Functional Relationships(s)
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1 Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal alpha-Helical Region of Htt. polyproline huntingtin Homo sapiens
2 Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal alpha-Helical Region of Htt. polyproline huntingtin Homo sapiens
3 Because tertiary interactions with a downstream (C-terminal) polyproline (polyP) region of htt may disrupt the formation of oligomers, which are precursors to fibrillar species, the effect of co-incubation of a region of htt with a 10-residue polyP peptide on oligomerization and fibrillization has been examined by atomic force microscopy. polyproline huntingtin Homo sapiens