Title : Roles of the G protein-coupled receptor kinase 2 and Rab5 in α1B-adrenergic receptor function and internalization.

Pub. Date : 2020 Jan 15

PMID : 31811856






2 Functional Relationships(s)
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1 Similarly, paroxetine and expression of the DN-GRK2 or the GDP-Rab5 mutants markedly decreased receptor internalization, alpha1B-adrenergic receptor phosphorylation, and attenuated the ability of the adrenergic agonist to induce homologous desensitization (calcium signaling). Guanosine Diphosphate RAB5A, member RAS oncogene family Homo sapiens
2 The possibility that Rab5 might form part of a signaling complex is suggested, as well as that GDP-Rab5 might interfere with the ability of GRK2 to catalyze alpha1B-adrenergic receptor phosphorylation. Guanosine Diphosphate RAB5A, member RAS oncogene family Homo sapiens