Title : Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion.

Pub. Date : 2020 Feb

PMID : 31801381






3 Functional Relationships(s)
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1 We hypothesized that a one-time administration of an adeno-associated virus (AAV) serotype rh.10 gene transfer vector expressing the human ALDH2 cDNA (AAVrh.10hALDH2) would persistently correct ALDH2 deficiency, prevent systemic accumulation of acetaldehyde, and reduce esophageal DNA damage and adducts accumulation from chronic ethanol ingestion. Acetaldehyde aldehyde dehydrogenase 2 family member Homo sapiens
2 We hypothesized that a one-time administration of an adeno-associated virus (AAV) serotype rh.10 gene transfer vector expressing the human ALDH2 cDNA (AAVrh.10hALDH2) would persistently correct ALDH2 deficiency, prevent systemic accumulation of acetaldehyde, and reduce esophageal DNA damage and adducts accumulation from chronic ethanol ingestion. Acetaldehyde aldehyde dehydrogenase 2 family member Homo sapiens
3 We hypothesized that a one-time administration of an adeno-associated virus (AAV) serotype rh.10 gene transfer vector expressing the human ALDH2 cDNA (AAVrh.10hALDH2) would persistently correct ALDH2 deficiency, prevent systemic accumulation of acetaldehyde, and reduce esophageal DNA damage and adducts accumulation from chronic ethanol ingestion. Acetaldehyde aldehyde dehydrogenase 2 family member Homo sapiens