Pub. Date : 2019 Nov
PMID : 31799659
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To explore the effect of micro-ribonucleic acid (miR)-187 on cisplatin (DDP) resistance of gastric cancer cells by regulating the transforming growth factor-beta (TGF-beta)/Smad signaling pathway. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | microRNA 187 | Homo sapiens |
| 2 | RESULTS: MiR-187 level had a negative correlation with DDP-resistance of GES-1, SGC7901, and SGC7901/DDP cells, and among them, the GES-1 cells had the lowest DDP-resistance and the highest expression of miR-187. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | microRNA 187 | Homo sapiens |
| 3 | RESULTS: MiR-187 level had a negative correlation with DDP-resistance of GES-1, SGC7901, and SGC7901/DDP cells, and among them, the GES-1 cells had the lowest DDP-resistance and the highest expression of miR-187. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | microRNA 187 | Homo sapiens |
| 4 | RESULTS: MiR-187 level had a negative correlation with DDP-resistance of GES-1, SGC7901, and SGC7901/DDP cells, and among them, the GES-1 cells had the lowest DDP-resistance and the highest expression of miR-187. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | microRNA 187 | Homo sapiens |
| 5 | CCK-8 assay revealed that compared with that in the control group, DDP-resistance significantly declined in the miR-187 mimic group, while it was significantly enhanced in miR-187 inhibitor group (p<0.01). | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | microRNA 187 | Homo sapiens |
| 6 | According to the results of flow cytometry, after treatment with 100 nM DDP for 12 h, the apoptotic rate in miR-187 mimic group enhanced, while it was markedly reduced in the miR-187 inhibitor group (p<0.01). | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | microRNA 187 | Homo sapiens |
| 7 | According to the results of flow cytometry, after treatment with 100 nM DDP for 12 h, the apoptotic rate in miR-187 mimic group enhanced, while it was markedly reduced in the miR-187 inhibitor group (p<0.01). | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | microRNA 187 | Homo sapiens |
| 8 | CONCLUSIONS: The overexpression of miR-187 alleviates DDP-resistance in gastric cancer cells by inhibiting the TGF-beta/Smad signaling pathway. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | microRNA 187 | Homo sapiens |