Title : Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases.

Pub. Date : 2019 Dec

PMID : 31798724






5 Functional Relationships(s)
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Protein Name
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1 CisPt decreased p53 protein phosphorylation in FaDu cells, but increased it in PE/CA-PJ49 cells. Platinum tumor protein p53 Homo sapiens
2 In this regard the CisPt treatment suggested that p53 phosphorylation is ERK1/2 independent in FaDu cells having a p53 gene deletion and ERK1/2 dependent in PE/CA-PJ49 cells having a p53 gene amplification. Platinum tumor protein p53 Homo sapiens
3 In this regard the CisPt treatment suggested that p53 phosphorylation is ERK1/2 independent in FaDu cells having a p53 gene deletion and ERK1/2 dependent in PE/CA-PJ49 cells having a p53 gene amplification. Platinum tumor protein p53 Homo sapiens
4 In this regard the CisPt treatment suggested that p53 phosphorylation is ERK1/2 independent in FaDu cells having a p53 gene deletion and ERK1/2 dependent in PE/CA-PJ49 cells having a p53 gene amplification. Platinum tumor protein p53 Homo sapiens
5 Moreover, in both tumor cell lines our results support the involvement of p53 phosphorylation-ERK1/2 activation-dependent in the apoptosis induced by combined treatments (CisPt and CRM). Platinum tumor protein p53 Homo sapiens