Title : Alteration of the DNA Methylation Signature of Renal Erythropoietin-Producing Cells Governs the Sensitivity to Drugs Targeting the Hypoxia-Response Pathway in Kidney Disease Progression.

Pub. Date : 2019

PMID : 31798631






2 Functional Relationships(s)
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1 We determined that hypoxia-inducible factor 2alpha (HIF2alpha), which is inactivated by HIF-prolyl hydroxylase domain-containing proteins (PHDs) in an oxygen-dependent manner, tightly regulates EPO production in REP cells at the gene transcription level to maintain oxygen homeostasis. Oxygen erythropoietin Homo sapiens
2 We determined that hypoxia-inducible factor 2alpha (HIF2alpha), which is inactivated by HIF-prolyl hydroxylase domain-containing proteins (PHDs) in an oxygen-dependent manner, tightly regulates EPO production in REP cells at the gene transcription level to maintain oxygen homeostasis. Oxygen erythropoietin Homo sapiens