Pub. Date : 2019
PMID : 31795034
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [18F]THK5351 uptake in progressive supranuclear palsy. | THK5351 | monoamine oxidase B | Homo sapiens |
| 2 | However, the interpretation of [18F]THK5351 uptake has been shown to be confounded by high monoamine oxidase B (MAO-B) availability across the brain in AD. | THK5351 | monoamine oxidase B | Homo sapiens |
| 3 | However, the interpretation of [18F]THK5351 uptake has been shown to be confounded by high monoamine oxidase B (MAO-B) availability across the brain in AD. | THK5351 | monoamine oxidase B | Homo sapiens |
| 4 | CONCLUSIONS: Similar to AD, the interpretation of [18F]THK5351 uptake in PSP is likely confounded by off-target binding to MAO-B binding sites. | THK5351 | monoamine oxidase B | Homo sapiens |