Pub. Date : 2020 Jun
PMID : 31792371
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the study was to validate the impact of the single-nucleotide polymorphism rs2413739 (T > C) in the PACSIN2 gene on thiopurines pharmacological parameters and clinical response in an Italian cohort of pediatric patients with acute lymphoblastic leukemia (ALL) and inflammatory bowel disease (IBD). | thiopurines | protein kinase C and casein kinase substrate in neurons 2 | Homo sapiens |
| 2 | Further evidence on PBMC and pediatric patients with IBD supports an association between PACSIN2 variants, TPMT activity, and thiopurines effects, even if more studies are needed since some of these effects may be tissue specific. | thiopurines | protein kinase C and casein kinase substrate in neurons 2 | Homo sapiens |