Title : Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells.

Pub. Date : 2020 Apr

PMID : 31789625






2 Functional Relationships(s)
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1 Metformin downregulated the levels of p-NF-kappaB p65, p-Erk1/2, p-AKT, and p-mTOR proteins. Metformin AKT serine/threonine kinase 1 Homo sapiens
2 Our discovery revealed that metformin, via increasing the expression of microRNA-7 mediated by AMPK, regulates the AKT/mTOR, MAPK/Erk, and NF-kappaB signaling pathways, thereby suppressing A549 cell growth, migration, and invasion. Metformin AKT serine/threonine kinase 1 Homo sapiens