Title : Requirements for DNA bubble structure for efficient cleavage by helix-two-turn-helix DNA glycosylases.

Pub. Date : 2020 Feb 13

PMID : 31784740






2 Functional Relationships(s)
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1 We have investigated the removal of 8-oxoguanine (8-oxoG) and 5,6-dihydrouracil (DHU) by Escherichia coli Fpg and Nei and human NEIL1 and NEIL2 from single-strand oligonucleotides, perfect duplexes, bubbles with different numbers of unpaired bases (6-30), bubbles containing the lesion in different positions and D-loops with the third strand made of DNA or RNA. 8-hydroxyguanine nei like DNA glycosylase 1 Homo sapiens
2 We have investigated the removal of 8-oxoguanine (8-oxoG) and 5,6-dihydrouracil (DHU) by Escherichia coli Fpg and Nei and human NEIL1 and NEIL2 from single-strand oligonucleotides, perfect duplexes, bubbles with different numbers of unpaired bases (6-30), bubbles containing the lesion in different positions and D-loops with the third strand made of DNA or RNA. 8-hydroxyguanine nei like DNA glycosylase 1 Homo sapiens