Title : Cyclic adenosine monophosphate-dependent activation of transient receptor potential vanilloid 4 (TRPV4) channels in osteoblast-like MG-63 cells.

Pub. Date : 2020 Feb

PMID : 31778738






4 Functional Relationships(s)
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1 Vanilloid transient potential (TRPV) channel inhibitor Ruthenium Red, but not a voltage-dependent calcium channel (VDCC) inhibitor nifedipine, efficiently stunted Ca2+ entry, and comparable abrogation was reproduced in cells treated with TRPV4-selective inhibitor RN-1734 or transfected with TRPV4-specific siRNA. Calcium transient receptor potential cation channel subfamily V member 4 Homo sapiens
2 Interestingly, PTH-driven Ca2+ through TRPV4 significantly inhibited MG63 cell migration through a mechanism requiring extracellular Ca2+. Calcium transient receptor potential cation channel subfamily V member 4 Homo sapiens
3 Interestingly, PTH-driven Ca2+ through TRPV4 significantly inhibited MG63 cell migration through a mechanism requiring extracellular Ca2+. Calcium transient receptor potential cation channel subfamily V member 4 Homo sapiens
4 Altogether, our results indicate that single treatment with PTH (1-34) promotes extracellular calcium entry through TRPV4 channels in MG-63 cells through a cAMP/PKA-dependent mechanism, and that this influx affects cell migration. Calcium transient receptor potential cation channel subfamily V member 4 Homo sapiens