Pub. Date : 2020 Feb
PMID : 31767456
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The steroid receptor coactivator 1 (SRC1) and 3 (SRC3) recruitment as a novel molecular initiating event of 4-n-nonylphenol in estrogen receptor alpha-mediated pathways. | 4-nonylphenol | estrogen receptor 1 | Homo sapiens |
| 2 | In MCF7 cell proliferation (E-SCREEN) assay and MVLN cell assay, 4-n-NP showed significant estrogenic potency that involved an increase in estrogen receptor alpha (ERalpha), SRC1 and SRC3 transcript levels. | 4-nonylphenol | estrogen receptor 1 | Homo sapiens |
| 3 | In MCF7 cell proliferation (E-SCREEN) assay and MVLN cell assay, 4-n-NP showed significant estrogenic potency that involved an increase in estrogen receptor alpha (ERalpha), SRC1 and SRC3 transcript levels. | 4-nonylphenol | estrogen receptor 1 | Homo sapiens |
| 4 | Moreover, 4-n-NP was found to induce estrogen response element (ERE)-mediated activity via ERalpha in MVLN cells. | 4-nonylphenol | estrogen receptor 1 | Homo sapiens |
| 5 | This is the first report to investigate the novel MIE of SRCs recruitment in 4-n-NP-ERalpha-induced estrogenicity. | 4-nonylphenol | estrogen receptor 1 | Homo sapiens |
| 6 | Overall, our results suggest that the action of 4-n-NP on estrogenic effects involves the following MIEs: the activation of ERalpha, the recruitment of SRC1 and SRC3, and the induction of ERE-mediated activity. | 4-nonylphenol | estrogen receptor 1 | Homo sapiens |