Title : Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease.

Pub. Date : 2020 Dec

PMID : 31760822






1 Functional Relationships(s)
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1 The BF framework aims to endow the conjugate molecules with ability for inhibition of AChE (bimodal way) and of amyloid-beta peptide aggregation, besides providing metal (Fe, Cu) chelating ability and concomitant extra anti-oxidant activity, for the hybrids with hydroxyl substitution. Copper acetylcholinesterase (Cartwright blood group) Homo sapiens