Title : Iron chelators inhibit amyloid-β-induced production of lipocalin 2 in cultured astrocytes.

Pub. Date : 2020 Jan

PMID : 31760034






4 Functional Relationships(s)
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1 Iron chelators inhibit amyloid-beta-induced production of lipocalin 2 in cultured astrocytes. Iron lipocalin 2 Homo sapiens
2 Iron chelators were found to reduce Lcn2 levels in certain animal models of CNS injury. Iron lipocalin 2 Homo sapiens
3 Focusing on Alzheimer"s disease (AD), we found that the iron chelators deferoxamine and deferiprone inhibited amyloid-beta (Abeta)-induced Lcn2 production in cultured primary astrocytes. Iron lipocalin 2 Homo sapiens
4 Known neuroprotective effects of iron chelators may rely in part on normalization of Lcn2 levels. Iron lipocalin 2 Homo sapiens