Title : Iguratimod dose dependently inhibits the expression of citrullinated proteins and peptidylarginine deiminases 2 and 4 in neutrophils from rheumatoid arthritis patients.

Pub. Date : 2020 Mar

PMID : 31758423






2 Functional Relationships(s)
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Protein Name
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1 IGU, MTX, and DXM dose dependently decreased the secretion of TNF-alpha, IL-1beta, IL-6, and IL-8 in neutrophils and PBMCs (P < 0.05); the inhibitory effect of IGU was not significantly different from that of MTX and DXM. Methotrexate tumor necrosis factor Homo sapiens
2 IGU, MTX, and DXM dose dependently decreased the secretion of TNF-alpha, IL-1beta, IL-6, and IL-8 in neutrophils and PBMCs (P < 0.05); the inhibitory effect of IGU was not significantly different from that of MTX and DXM. Methotrexate tumor necrosis factor Homo sapiens