Title : β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cells.

Pub. Date : 2020 Jan

PMID : 31757742






2 Functional Relationships(s)
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1 We found that betaOHB significantly enhanced cisplatin-induced apoptosis and cleavage of caspase-3 and -8 in HCC cells. Cisplatin caspase 3 Homo sapiens
2 In HDAC3/6 gene silencing, survivin expression was significantly decreased, and cisplatin-induced cleavage of caspase-3 was significantly enhanced compared with control in HepG2 cells. Cisplatin caspase 3 Homo sapiens