Pub. Date : 2020 Feb
PMID : 31748116
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |
| 2 | Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |
| 3 | However, the pathogenic mechanisms driving Gd-IgA1 production have not been fully elucidated. | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |
| 4 | Innate-immune activation via Toll-like receptor 9 (TLR9) is known to be involved in Gd-IgA1 production. | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |
| 5 | A proliferation inducing ligand (APRIL) and IL-6 are also known to enhance Gd-IgA1 synthesis in IgAN. | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |
| 6 | However, siRNA knock-down of APRIL completely suppressed overproduction of Gd-IgA1 induced by IL-6. | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |
| 7 | Neutralization of IL-6 decreased CpG-oligonucleotide-induced overproduction of Gd-IgA1. | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |
| 8 | Furthermore, APRIL and IL-6 pathways each independently mediated TLR9-induced overproduction of Gd-IgA1. | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |
| 9 | Hence, APRIL and IL-6 synergistically, as well as independently, enhance synthesis of Gd-IgA1. | Gadolinium | immunoglobulin heavy constant alpha 1 | Homo sapiens |