Pub. Date : 2020 Jan 15
PMID : 31740393
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Drug-drug interaction between crizotinib and entecavir via renal secretory transporter OCT2. | Crizotinib | solute carrier family 22 member 2 | Homo sapiens |
| 2 | Both entecavir and crizotinib are substrates of organic cation transporter 2 (OCT2). | Crizotinib | solute carrier family 22 member 2 | Homo sapiens |
| 3 | Both entecavir and crizotinib are substrates of organic cation transporter 2 (OCT2). | Crizotinib | solute carrier family 22 member 2 | Homo sapiens |
| 4 | Kinetic constants for crizotinib uptake by OCT2 were Km 1.16 +- 0.26 microM, Vmax 12.05 +- 0.53 micromol/min mg-1 protein and Ki 9.711 nM. | Crizotinib | solute carrier family 22 member 2 | Homo sapiens |
| 5 | Entecavir can inhibit crizotinib transport by OCT2 in kidney. | Crizotinib | solute carrier family 22 member 2 | Homo sapiens |