Pub. Date : 2019
PMID : 31736966
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. | Naltrexone | transient receptor potential cation channel subfamily M member 3 | Homo sapiens |
| 2 | Naltrexone hydrochloride (NTX) acts as an antagonist to the muOR thus negating the inhibitory function of this opioid receptor on TRPM3. | Naltrexone | transient receptor potential cation channel subfamily M member 3 | Homo sapiens |
| 3 | Naltrexone hydrochloride (NTX) acts as an antagonist to the muOR thus negating the inhibitory function of this opioid receptor on TRPM3. | Naltrexone | transient receptor potential cation channel subfamily M member 3 | Homo sapiens |
| 4 | Therefore, understanding the mechanism of action for NTX in regulating and modulating TRPM3 channel function in NK cells will provide important information for the development of effective therapeutic interventions for ME/CFS. | Naltrexone | transient receptor potential cation channel subfamily M member 3 | Homo sapiens |
| 5 | Importantly, TRPM3 channel activity was restored in IL-2 stimulated NK cells isolated from ME/CFS patients after incubation for 24 h with NTX. | Naltrexone | transient receptor potential cation channel subfamily M member 3 | Homo sapiens |
| 6 | Moreover, we demonstrated that NTX does not act as an agonist by directly coupling on the TRPM3 ion channel gating. | Naltrexone | transient receptor potential cation channel subfamily M member 3 | Homo sapiens |
| 7 | The opioid antagonist NTX has the potential to negate the inhibitory function of opioid receptors on TRPM3 in NK cells from ME/CFS patients, resulting in calcium signals remodeling, which will in turn affect cell functions, supporting the hypothesis that NTX may have potential for use as a treatment for ME/CFS. | Naltrexone | transient receptor potential cation channel subfamily M member 3 | Homo sapiens |
| 8 | The opioid antagonist NTX has the potential to negate the inhibitory function of opioid receptors on TRPM3 in NK cells from ME/CFS patients, resulting in calcium signals remodeling, which will in turn affect cell functions, supporting the hypothesis that NTX may have potential for use as a treatment for ME/CFS. | Naltrexone | transient receptor potential cation channel subfamily M member 3 | Homo sapiens |