Pub. Date : 2019 Dec
PMID : 31735555
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway. | Calcium Oxalate | H19 imprinted maternally expressed transcript | Homo sapiens |
| 2 | A recent genome-wide gene expression profile analysis of Randall"s plaques in CaOx stone patients revealed that the expression of the long noncoding RNA H19 was significantly upregulated. | Calcium Oxalate | H19 imprinted maternally expressed transcript | Homo sapiens |
| 3 | Moreover, H19 downregulation inhibited HMGB1, TLR4 and NF-kappaB expression and suppressed CaOx nephrocalcinosis-induced renal tubular epithelial cell injury, NADPH oxidase, and oxidative stress in vivo and in vitro. | Calcium Oxalate | H19 imprinted maternally expressed transcript | Homo sapiens |
| 4 | INTERPRETATION: We determined that H19 might serve as a facilitator in the process of CaOx nephrocalcinosis-induced oxidative stress and renal tubular epithelial cell injury, and we revealed that the interaction between H19 and miR-216b could exert its effect via the HMGB1/TLR4/NF-kappaB pathway. | Calcium Oxalate | H19 imprinted maternally expressed transcript | Homo sapiens |