Title : Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells.

Pub. Date : 2020 Jan 15

PMID : 31733235






2 Functional Relationships(s)
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1 It was reported that rat CYP1A1 and catfish CYP1A can hydroxylate 3,3",4,4",5-pentachlorobiphenyl (PCB 126) and 3,3",4,4"-tetrachlorobiphenyl (PCB 77), while potential roles of other CYP1 enzymes in the metabolism of dioxin-like (DL) PCBs remain unconfirmed. Dioxins pyruvate carboxylase Homo sapiens
2 It was reported that rat CYP1A1 and catfish CYP1A can hydroxylate 3,3",4,4",5-pentachlorobiphenyl (PCB 126) and 3,3",4,4"-tetrachlorobiphenyl (PCB 77), while potential roles of other CYP1 enzymes in the metabolism of dioxin-like (DL) PCBs remain unconfirmed. Dioxins pyruvate carboxylase Homo sapiens