Title : PRC2-complex related dysfunction in overgrowth syndromes: A review of EZH2, EED, and SUZ12 and their syndromic phenotypes.

Pub. Date : 2019 Dec

PMID : 31724824






1 Functional Relationships(s)
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Protein Name
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1 The EZH2, EED, and SUZ12 genes encode proteins that comprise core components of the polycomb repressive complex 2 (PRC2), an epigenetic "writer" with H3K27 methyltransferase activity, catalyzing the addition of up to three methyl groups on histone 3 at lysine residue 27 (H3K27). 3-O-methyl-alpha-methyldopamine SUZ12 polycomb repressive complex 2 subunit Homo sapiens