Pub. Date : 2020 Mar 1
PMID : 31724712
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-144 Mediates High Fat-Induced Changes of Cholesterol Metabolism via Direct Regulation of C/EBPalpha in the Liver and Isolated Hepatocytes of Yellow Catfish. | Cholesterol | microRNA 144 | Homo sapiens |
| 2 | miR-144 directly targeted hydroxymethylglutaryl-CoA reductase (hmgcr), cholesterol 7alpha-monooxygenase A1 (cyp7a1), and adenosine triphosphate binding cassette transporter A1 (abca1) in HEK293T cells. | Cholesterol | microRNA 144 | Homo sapiens |
| 3 | In the hepatocytes of yellow catfish, miR-144 inversely regulated the expression of hmgcr, cyp7a1, and abca1 (30.3-78.5%, P < 0.05); loss of miR-144 function alleviated PA- or OA-induced cholesterol accumulation (19.5-61.1%, P < 0.05). | Cholesterol | microRNA 144 | Homo sapiens |
| 4 | CONCLUSIONS: miR-144 mediated HFD-induced changes in the liver and hepatocytes of yellow catfish, suggesting a possible mechanism for HFD-induced dysfunction in cholesterol metabolism. | Cholesterol | microRNA 144 | Homo sapiens |