Title : Synergistic induction of drug-metabolizing enzymes in co-cultures of bovine hepatocytic and sinusoidal cell lines.

Pub. Date : 2020 Jan

PMID : 31722089






3 Functional Relationships(s)
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1 A potent carcinogen, 3-methylcholanthrene (3-MC), upregulated gene expression of cytochrome P450 (CYP)1A1, CYP1A2, and CYP1B1 in BH4 and BH5, but only to levels less than one-fifteenth of those in primary cultured bovine hepatocytes. Hydrogen [(1r)-1-Hydroxy-2-(3-Pentadecyl-1h-Imidazol-3-Ium-1-Yl)-1-Phosphonoethyl]phosphonate cytochrome P450 1B1 Bos taurus
2 By contrast, when BH4 or BH5 was co-cultured with previously established bovine liver sinusoidal cell lines and treated with 3-MC, the gene expression levels of CYP1A1, CYP1A2, and CYP1B1 increased by 38~290%, compared with those in BH4 or BH5 cells cultured alone. Hydrogen [(1r)-1-Hydroxy-2-(3-Pentadecyl-1h-Imidazol-3-Ium-1-Yl)-1-Phosphonoethyl]phosphonate cytochrome P450 1B1 Bos taurus
3 By contrast, when BH4 or BH5 was co-cultured with previously established bovine liver sinusoidal cell lines and treated with 3-MC, the gene expression levels of CYP1A1, CYP1A2, and CYP1B1 increased by 38~290%, compared with those in BH4 or BH5 cells cultured alone. Hydrogen [(1r)-1-Hydroxy-2-(3-Pentadecyl-1h-Imidazol-3-Ium-1-Yl)-1-Phosphonoethyl]phosphonate cytochrome P450 1B1 Bos taurus