Title : Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition.

Pub. Date : 2019 Nov 9

PMID : 31717492






1 Functional Relationships(s)
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1 In cell-based assays for CDK8 and CDK19 inhibition, Cmpd3, Cmpd4, dCA and 15w showed similar low-nanomolar potency and efficacy against CDK8 and CDK19, while Senexin B was less potent. didehydro-cortistatin A cyclin-dependent kinase 19 Danio rerio