Title : Self-assembled peptide nanoparticles responsive to multiple tumor microenvironment triggers provide highly efficient targeted delivery and release of antitumor drug.

Pub. Date : 2019 Dec 28

PMID : 31682910






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Herein, a multifunctional peptide (P51) was developed for programmed delivery of the hydrophobic chemotherapeutic agent pirarubicin. pirarubicin tumor protein p63 Homo sapiens
2 Self-assembly of P51 and pirarubicin (P51-THP NPs) results into stable spherical nanoparticles in a single step. pirarubicin tumor protein p63 Homo sapiens
3 We demonstrate that the acid environment, DTT, and MMP-2 stimulated the release of pirarubicin from P51-THP NPs and, more importantly, the efficiency of drug release is markedly increased when all three release triggers are present. pirarubicin tumor protein p63 Homo sapiens