Title : Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis.

Pub. Date : 2019

PMID : 31667337






1 Functional Relationships(s)
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1 Wnt5a also induced ROR1-dependent tyrosine phosphorylation of cortactin (Y421), which recruited ARHGEF1 to activate RhoA and promote breast-cancer-cell migration; such effects could be inhibited by cirmtuzumab, a humanized mAb specific for ROR1. Tyrosine ras homolog family member A Mus musculus