Pub. Date : 2019
PMID : 31661694
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To investigate whether TRIAP1inhibition affects the ovarian cancer cell resistance to cisplatin (DDP) via the Cyt c/Apaf-1/caspase-9 pathway by in vitro and in vivo experiments. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | TP53 regulated inhibitor of apoptosis 1 | Homo sapiens |
| 2 | METHODS: CCK8 assay was performed to find out how treatment with both TRIAP1 siRNA and DDP affects the cell viability of SKOV3 cells and DDP-resistant human ovarian carcinoma cell line SKOV3/DDP. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | TP53 regulated inhibitor of apoptosis 1 | Homo sapiens |
| 3 | METHODS: CCK8 assay was performed to find out how treatment with both TRIAP1 siRNA and DDP affects the cell viability of SKOV3 cells and DDP-resistant human ovarian carcinoma cell line SKOV3/DDP. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | TP53 regulated inhibitor of apoptosis 1 | Homo sapiens |
| 4 | The proliferation rate was lower in SKOV3/DDP cells transfected with TRIAP1 siRNA combined with treatment of DDP (1, 2, 4, 6, 8, 16, 32 mug/mL) than in those transfected with control siRNA. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | TP53 regulated inhibitor of apoptosis 1 | Homo sapiens |
| 5 | Moreover, the TRIAP1 siRNA group had an increased SKOV3/DDP cell apoptosis rate with the activation of the Cyt c/Apaf-1/caspase-9 pathway. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | TP53 regulated inhibitor of apoptosis 1 | Homo sapiens |
| 6 | CONCLUSION: TRIAP1 inhibition may enhance the sensitivity of SKOV3/DDP cells to cisplatin via activation of the Cyt c/Apaf-1/caspase-9 pathway. | 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate | TP53 regulated inhibitor of apoptosis 1 | Homo sapiens |