Title : Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum.

Pub. Date : 2019 Oct 28

PMID : 31661019






3 Functional Relationships(s)
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1 Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum. Serine D-amino acid oxidase Mus musculus
2 Dynamic demethylation at two specific CpG sites located just downstream of the transcription start site was sufficient to strongly activate the Dao gene, ultimately promoting the complete physiological degradation of cerebellar D-serine a few days after mouse birth. Serine D-amino acid oxidase Mus musculus
3 CONCLUSION: The present investigation demonstrates that robust and selective demethylation of two CpG sites is associated with postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum. Serine D-amino acid oxidase Mus musculus