Pub. Date : 2020 Jan 1
PMID : 31647972
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Capsaicin, an agonist of TRPV1, evokes intracellular [Ca2+] transients and glutamate release from perfused trigeminal ganglion. | Calcium | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 2 | PnTx3-5 (40 nM) and SB-366791 (3 muM) also inhibited the capsaicin-induced increase in intracellular Ca2+ in HEK293 cells transfected with TRPV1 by 75 +- 16 % and 84 +- 3.2 %, respectively. | Calcium | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 3 | In HEK293 cells transfected with TRPA1, cinnamaldehyde (30 muM) generated an increase in intracellular Ca2+ that was blocked by the TRPA1 antagonist HC-030031 (10 muM, 89% inhibition), but not by PnTx3-5 (40 nM), indicating selectivity of the toxin for TRPV1. | Calcium | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |