Pub. Date : 2019 Oct 22
PMID : 31640742
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51. | Metformin | RAD51 recombinase | Homo sapiens |
| 2 | Metformin suppressed cisplatin-mediated RAD51 upregulation by decreasing RAD51 protein stability and increasing its ubiquitination. | Metformin | RAD51 recombinase | Homo sapiens |
| 3 | Metformin suppressed cisplatin-mediated RAD51 upregulation by decreasing RAD51 protein stability and increasing its ubiquitination. | Metformin | RAD51 recombinase | Homo sapiens |
| 4 | Overexpression of RAD51 blocked the metformin-induced inhibition of cell migration and invasion, while RAD51 knockdown enhanced cisplatin activity. | Metformin | RAD51 recombinase | Homo sapiens |
| 5 | CONCLUSIONS: Metformin enhances anticancer effect of cisplatin by downregulating RAD51 expression, which represents a novel therapeutic target in TNBC management. | Metformin | RAD51 recombinase | Homo sapiens |