Pub. Date : 2019 Dec 1
PMID : 31633177
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin-E2 deficiency during late pregnancy and the associated increase in interleukin-1beta derived from periaortic lymph nodes lead to abortion. | Dinoprostone | interleukin 1 beta | Mus musculus |
| 2 | Further, through RNA sequencing, we reveal that PLNs produce a large amount of interleukin-1beta (IL-1beta) when exposed to PGE2 deficiency, which causes damage to the placental labyrinth, probably via destroying the extracellular matrix. | Dinoprostone | interleukin 1 beta | Mus musculus |
| 3 | Further, through RNA sequencing, we reveal that PLNs produce a large amount of interleukin-1beta (IL-1beta) when exposed to PGE2 deficiency, which causes damage to the placental labyrinth, probably via destroying the extracellular matrix. | Dinoprostone | interleukin 1 beta | Mus musculus |
| 4 | These results suggest that high levels of PGE2 during late pregnancy protect fetuses from inflammatory damage related to IL-1beta. | Dinoprostone | interleukin 1 beta | Mus musculus |