Title : Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity.

Pub. Date : 2019 Dec

PMID : 31628911






1 Functional Relationships(s)
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1 The upregulation of genes related to bile acid synthesis (CYP7A1 and CYP8B1) and the downregulation of genes related to conjugation (BAAT and BACS) and regulation (FXR and SHP) were detected in the liver, suggesting that hydrophobic bile acid production was increased and FXR signaling was impaired. Bile Acids and Salts bile acid-CoA:amino acid N-acyltransferase Homo sapiens